I have deep creases around my mouth, hereditary I believe, my female relatives all have them. All are non-smokers. Anyway, I have been using the frownies for two weeks and I'm amazed at the response. I was a bit skeptical, but I heard of these when I was in my 20's, then saw an article about them recently. Thought, what do I have to lose but wrinkles? I will keep using them, this product actually works. I have spent tons of money on retinol products, hydrating products...all that stuff, some helped a bit, but not this dramatically. Wish I had snapped a selfie before I started, but who wants to see that stuff up close? Thank you so much for this product!