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Apple Serum-Malus Domestica-Apple Stem Cell Extract

Apple Serum-Malus Domestica-Apple Stem Cell Extract

15-1ml ampoules for easy application and less preservatives!

Love this serum!

I’ve been using the Frownies Apple Serum for over a month twice a day and really love it! I feel like I’m starting to see a difference in the fine lines around my eyes. Love how the serum feels and how hydrating to my skin it is. Will keep this as a staple in my skin care.


SOF Journal article on Apple Stem Cell

An Apple a day Stem cell research    

Fruit derived stem cell for skin care                                                            


Wash your face with the Frownies PH Balancing Face Wash and then apply a pea size amount of Frownies Apple Stem Cell Serum concentrating on the area around the eyes, mouth, neck, or anywhere where you notice more fine lines and thinning of the skin.

After applying the Apple Stem Cell Serum pop the top back on the ampule for later use.


Malus Domestica is a unique apple that grows in the Alps of northern Switzerland. Once picked the apple stays fresh months longer than ordinary fruit without shriveling or wrinkling.

Studies show that apple stem cells decreased wrinkles; boosting production of human stem cells. When tested in vitro (in a lab), the apple stem cell extract was applied to human stem cells and was found to increase the number of the stem cells in the culture.

Apply the Apple Stem Cell Serum to the skin on the face and neck twice daily (morning and evening). We recommend using the Apple Stem Cell Serum under your daily moisturizer or night crème as an enhancement to the other hydrating ingredients.

The Apple Stem Cell Serum is packaged in a biodegradable ampule. The small ampule prevents the need for additional preservatives and ensures the potency of the ingredients.

We are looking for sustainable packaging solutions, and terms such as recyclable, compostable, and biodegradable are commonly used together, often interchangeably, they refer to different processes.
Biodegradable plastics are not compostable they do decompose much faster than their traditional counterparts which may take hundreds of years to break down. They seem, therefore, a more environmentally friendly solution.
The conversation about which packaging (recyclable, biodegradable or compostable) is best for the environment is ongoing and there’s no single answer to this question. All of these solutions come with their own benefits and limitations but are Frownies step forward in considering more sustainable alternatives to standard packaging.


Aqua, Malus Domestica Fruit Cell Culture Extract Glycerin, Peg-2m, Butylene Glycol, Hydroxyethyl Urea, Carnosine (peptide), Xanthan Gum,Lecithin, Trehalose, Sodium Lactate, Allantoin, 1,2-hexanediol, Tremella Fuciformis (Mushroom) Extract, Polyacrylate Cross- Polymer-6, Pentylene Glycol, Avena Sativa (Oat) Kernel Extract, Portulaca Oleracea Extract, Propylene Glycol, Lactic Acid.

Many of the ingredients are from around the world and we have a certificate of analysis for every ingredient certifying its purity and stability.

The lab where the product is manufactured has a Good Manufacturing Process Certification has passed 1SO22716 which gives guidelines for the production, control, storage and shipment of cosmetic products. These guidelines cover the quality aspects of the product, The lab has passed US FDA Cosmetic Good Manufacturing Practice Certification as well.

All Frownies products are the highest quality ingredients and manufacturing processes.


Q: What's the difference between the Apple Stem Cell Serum and the Frownies Skin Serum?

A: The Frownies Skin Serum is a facial oil with high concentration of naturally occurring Vitamin C and Vitamin meant to lock in moisture and provide beneficial antioxidants to the skin. The Apple Stem Cell Serum is meant to fight the affects of aging and improve stem cell production in the skin. Frownies Skin Serum and Frownies Apple Stem Cell Serum are complimentary and should be used together for greatest impact!

Q: How many ampules come in a box?

A: There are 15 ampules in each box.

Q: How many uses can I get from one ampule?

A: If you are applying the serum to your face and neck you can use 1/2 an ampule in the morning and 1/2 at night. If you are concentrating only on the area around the eyes and mouth you might be able to get 3 or 4 uses out of one ampule (using a few drops at a time).

Q: How long will it take to see results?

A: When it comes to skin care it can take up to 12 weeks for full cell turnover so remember that consistent use over time will produce the best results. Be consistent using the Apple Stem Cell Serum twice a day for best results.

Q: Do I need to use a moisturizer after applying the Apple Stem Cell Serum.

A: Yes, we recommend using the Frownies Moisturizers for Face and Neck.


We are so confident you will see results with continuous use of Frownies wrinkle patches and skin care products, that we will refund the purchase price (excluding shipping and handling paid by B&P Company Inc) if your not happy with the benifits. 

Simply return your product within 30 days of purchase. All returns must be in their original package, and accompanied by the original invoice from Frownies.

You may call customer service at 800-648-6891 with any questions. Our business hours are from 8:00 am to 4:00 pm EST Monday through Thursday and 8:00 am  to 12:00 pm Fridays EST

Please address all returns to:

Frownies Guarantee
ATTN: Customer Service 
97 Compark Road
Centerville, OH 45459


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Customer Reviews

Based on 58 reviews
Gail Aiken

It feels wonderful and light. My skin seem softer.

Hi Gail, thank you for your review! We're so happy you're enjoying Frownies Apple Serum. We love how hydrating and effective the serum is, especially around the eyes and mouth! If you have any questions, please don't hesitate to message us on Many thanks, Frownies Customer Care


Love the Apple Serum….actually started using on my hands as well and see an amazing difference of appearance when using. This product is a Win Win for me!

Amanda, thanks so much for the review! We're so glad to hear you're enjoying the Apple Serum. We love when customers experiment with our products and find even more uses for them that are beneficial. If you ever have any questions, please don't hesitate to message us on We appreciate you!! - Frownies Customer Care

Britin Cross
Ingredients are different

The ingredients on the actual box are different than on your website. Box says propylene glycol. This list does not.

Hi Britin, thank you for your review. We appreciate you bringing this to our attention. We've gone ahead and notified our team so the corrections can be made! If you have any other questions or feedback, feel free to message us on or email Take care, Frownies Customer Care

mary kate
Customer for life

I love this product! In combination with the under eye gels I have seen a noticeable difference in my crows feet/under eye area

Hi Mary Kate, thank you for your review! We're so glad you've noticed such a change in your eye area from the Apple Serum and Under Eye Gels! There's a fun promo happening in December that involves both of these, if you'd like to stock up! Check out for more information or message us on All our best, Frownies Customer Care

Love this stuff!

It absorbs quick into my skin and leaves it so hydrated! I apply it and do my frownies and in the morning my fine lines are gone!

Hi Shannon, thanks so much for your review! We're so happy to hear you're loving the Apple Serum. It really is so hydrating and the perfect product to incorporate to a skincare routine! If you plan to purchase again this month, you'll receive a free set of Under Eye Gels if you use code: APPLE at check out! Email us if you have any questions: Many thanks, Frownies Customer Care