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The Frownies

Apple Serum-Malus Domestica-Apple Stem Cell Extract

Apple Serum-Malus Domestica-Apple Stem Cell Extract

39 total reviews

Regular price $37.95
Regular price $37.95 Sale price $37.95
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15-1ml ampoules for easy application and less preservatives!

SOF Journal article on Apple Stem Cell

An Apple a day Stem cell research    

Fruit derived stem cell for skin care                                                            


Wash your face with the Frownies PH Balancing Face Wash and then apply a pea size amount of Frownies Apple Stem Cell Serum concentrating on the area around the eyes, mouth, neck, or anywhere where you notice more fine lines and thinning of the skin.

After applying the Apple Stem Cell Serum pop the top back on the ampule for later use.


Malus Domestica is a unique apple that grows in the Alps of northern Switzerland. Once picked the apple stays fresh months longer than ordinary fruit without shriveling or wrinkling.

Studies show that apple stem cells decreased wrinkles; boosting production of human stem cells. When tested in vitro (in a lab), the apple stem cell extract was applied to human stem cells and was found to increase the number of the stem cells in the culture.

Apply the Apple Stem Cell Serum to the skin on the face and neck twice daily (morning and evening). We recommend using the Apple Stem Cell Serum under your daily moisturizer or night crème as an enhancement to the other hydrating ingredients.

The Apple Stem Cell Serum is packaged in a biodegradable zero plastic ampule. The small ampule prevents the need for additional preservatives and ensures the potency of the ingredients.


Malus Domestica Fruit Cell Culture Extract, Hydroxyethyl Urea, Carnosine, Lecithin, Trehalose, Sodium Lactate, Allantoin, Tremella Fuciformis (Mushroom)Extract, Avena Sativa (Oat) Kernel Extract, Portulaca Oleracea Extract.


Q: What's the difference between the Apple Stem Cell Serum and the Frownies Skin Serum?

A: The Frownies Skin Serum is a facial oil with high concentration of naturally occurring Vitamin C and Vitamin meant to lock in moisture and provide beneficial antioxidants to the skin. The Apple Stem Cell Serum is meant to fight the affects of aging and improve stem cell production in the skin. Frownies Skin Serum and Frownies Apple Stem Cell Serum are complimentary and should be used together for greatest impact!

Q: How many ampules come in a box?

A: There are 15 ampules in each box.

Q: How many uses can I get from one ampule?

A: If you are applying the serum to your face and neck you can use 1/2 an ampule in the morning and 1/2 at night. If you are concentrating only on the area around the eyes and mouth you might be able to get 3 or 4 uses out of one ampule (using a few drops at a time).

Q: How long will it take to see results?

A: When it comes to skin care it can take up to 12 weeks for full cell turnover so remember that consistent use over time will produce the best results. Be consistent using the Apple Stem Cell Serum twice a day for best results.

Q: Do I need to use a moisturizer after applying the Apple Stem Cell Serum.

A: Yes, we recommend using the Frownies Moisturizers for Face and Neck.


We are so confident you will see results before the end of your first month of continuous use of our Facial Patches, that if your frown lines do not show any signs of improvement, we will refund purchase.

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Customer Reviews

Based on 39 reviews
Great product

I love this product. I use it around my eyes nightly and spread any extra all over. It truly has made such an incredible improvement to not only softening the lines around my eyes but also improving my face. From less redness and less noticeable pores to just overall improving the softness to my face. I highly recommend!

Hi Sandra, thanks so much for your review! We're so happy to hear you're enjoying the Apple Serum and that you're experiencing such great results from it. If you haven't joined us on social media, check out or We appreciate you!! - Frownies Customer Care

Wowza! 5-Star!

I can't wait to see the long term effects of the Apple Serum Extract because in the short amount of time I have used it, I have already been extremely pleased. I have had a tiny bump under my right eye that appeared to be a clogged pore for the eight weeks. I went to an Esthetician because I needed professional help getting it extracted. She had no success and said it must be a Merkel cell carcinoma or a mass of cells forming and suggested I see a Dermatologist. I booked an appointment with my Dermatologist and haven't been able to get in because of their schedule. I recently purchased the Apple Serum and thought I might as well get it a try on the small bump on my face. Sure enough after three days of putting the serum on the bump, the bump came to a "head" and is in the process of healing. I had literally tried everything under the sun and had no success until the Apple Serum.

Hi Chloe, thanks for your review! While the Apple Serum wasn't produced for that reason, our customers always seem to find creative ways to use our products and we're always glad to hear when they work out. Thanks for sharing your experience!! We hope you'll continue loving the product. If you haven't yet, please join us on or Many thanks, Frownies Customer Care

Hillary Soring
Love! Wish it came in a jar, though!

I have ordered the Apple Serum twice now and I do see a difference from consistent use over several weeks. I feel like I would continue to use it/reorder more if it came in a jar or dropper form!

Hi Hillary, thanks for your review. We're happy to hear you're enjoying the Apple Serum! The reason the serum is packaged in individual ampoules is to maintain the potency and freshness of the ingredients. It helps keep the serum as effective as possible when you only open each vial as needed. The packaging is not made from plastic and is biodegradable, if that is a concern of yours! If you have any further questions, please feel free to message us on or Thanks so much, Frownies Customer Care

Jennifer Willett

Apple Serum-Malus Domestica-Apple Stem Cell Extract

Hi Jennifer, thanks so much for leaving a review. We’re happy to see you’re enjoying the Apple Serum! If you haven’t yet, please join us on or We appreciate you!! - Frownies Customer Care

Amazing results!!

Frownies Apple Serum-Malus Domestica-Apple Stem Cell serum has been a game changer for the under eye fine lines and the wrinkles around my mouth.

Hi Kathleen, thank you for your review of our Apple Serum! It's been such a popular product since it's recent launch this past spring because of the amazing results it provides. We're so happy you're enjoying it. If you haven't yet, please join us on or We appreciate you!! - Frownies Customer Care